Article
Cognitive impairment in patients with multiple sclerosis: association with the APOE gene and promoter polymorphisms.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jan 2007
Parmenter B A, Denney D R, Lynch S G, Middleton L S, Harlan L M
Abstract excerpt
BACKGROUND: Studies examining the epsilon4 allele of the APOE gene as a factor affecting the severity of multiple sclerosis (MS) have yielded conflicting results. The focus of these studies on physical disability to the neglect of cognitive impairment is surprising in light of the associations between the epsilon4 allele and other dementia conditions. Only two studies examine the relationship between the epsilon4...
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