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Article

APOE-epsilon4 is not associated with cognitive impairment in relapsing-remitting multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Dec 2009

Portaccio Emilio, Goretti Benedetta, Zipoli Valentina, Nacmias Benedetta, Stromillo Maria Laura, Bartolozzi Maria Letizia, Siracusa Gianfranco, Guidi Leonello, Federico Antonio, Sorbi Sandro, De Stefano Nicola, Amato Maria Pia

Abstract excerpt

The objective of this article was to assess the association between apolipoprotein E (APOE)-epsilon4 and cognitive impairment (CI) in relapsing-remitting multiple sclerosis (RRMS). The APOE genotype was assessed in 85 RRMS cases (58 females, mean age 43 +/- 8.4 years, mean disease duration 15.8 +/- 9.6 years, mean Expanded Disability Status Scale (EDSS) 1.7 +/- 1.0). Cognitive functioning was evaluated in the...

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Source

Identifiers

PMID: 19965518
DOI: 10.1177/1352458509348512

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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