Article
Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis.
Journal of neurology - 1 Oct 2004
Savettieri Giovanni, Messina Demetrio, Andreoli Virginia, Bonavita Simona, Caltagirone Carlo, Cittadella Rita, Farina Deborah, Fazio Maria Carolina, Girlanda Paolo, Le Pira Francesco, Liguori Maria, Lugaresi Alessandra, Nocentini Ugo, Reggio Arturo, Salemi Giuseppe, Tedeschi Gioacchino, Trojano Maria, Valentino Paola, Quattrone Aldo
Abstract excerpt
BACKGROUND: Cognitive impairment may occur at any time during the course of multiple sclerosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-epsilon4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons. OBJECTIVE: To investigate the...
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