Article
Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis.
Clinical and translational gastroenterology - 1 Apr 2020
Pereira Márcia S, Durães Cecília, Catarino Telmo A, Costa José L, Cleynen Isabelle, Novokmet Mislav, Krištić Jasminka, Štambuk Jerko, Conceição-Neto Nádia, Machado José C, Marcos-Pinto Ricardo, Magro Fernando, Vermeire Séverine, Lauc Gordan, Lago Paula, Pinho Salomé S
Abstract excerpt
OBJECTIVES: The impact of genetic variants (single nucleotide polymorphisms [SNPs]) in the clinical heterogeneity of ulcerative colitis (UC) remains unclear. We showed that patients with UC exhibit a deficiency in MGAT5 glycogene transcription in intestinal T cells associated with a hyperimmune response. Herein, we evaluated whether MGAT5 SNPs might functionally impact on T cells glycosylation and plasma IgG...
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