Article
Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome.
Inflammatory bowel diseases - 1 Jun 2015
Trbojević Akmačić Irena, Ventham Nicholas T, Theodoratou Evropi, Vučković Frano, Kennedy Nicholas A, Krištić Jasminka, Nimmo Elaine R, Kalla Rahul, Drummond Hazel, Štambuk Jerko, Dunlop Malcolm G, Novokmet Mislav, Aulchenko Yurii, Gornik Olga, Campbell Harry, Pučić Baković Maja, Satsangi Jack, Lauc Gordan
Abstract excerpt
BACKGROUND: Glycobiology is an underexplored research area in inflammatory bowel disease (IBD), and glycans are relevant to many etiological mechanisms described in IBD. Alterations in N-glycans attached to the immunoglobulin G (IgG) Fc fragment can affect molecular structure and immunological function. Recent genome-wide association studies reveal pleiotropy between IBD and IgG glycosylation. This study aims to...
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