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Article

Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens

20 May 2010

Abstract excerpt

BACKGROUND: High antibody reactivity toward microbial antigens in Crohn's disease (CD) patients is predictive of a more aggressive disease course. However, few ulcerative colitis (UC) patients exhibit serologic reactivity toward microbial antigens. Mucosal expression of IFN-γ plays a pivotal role in inflammatory bowel disease (IBD) pathogenesis. Recent genome-wide association studies (GWAS) surprisingly link UC,...

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PMID: 20848535
DOI: 10.1002/ibd.21352

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