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Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease

4 Jun 2018

Abstract excerpt

Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations between genetic and epigenetic changes and IBD. Independent GWA studies have identified genetic variants in the BACH2 , IL6ST , LAMB1 , IKZF1 , and MGAT3 loci to be associated with both IBD and immunoglobulin G...

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PMID: 29991969
DOI: 10.1186/s13148-018-0507-y

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