Article
Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues.
Frontiers in immunology - 1 Jan 2021
Li Xingang, Wang Hao, Zhu Yahong, Cao Weijie, Song Manshu, Wang Youxin, Hou Haifeng, Lang Minglin, Guo Xiuhua, Tan Xuerui, Han Jingdong J, Wang Wei
Abstract excerpt
Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with immunoglobulin G (IgG) N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain. Leveraging data from GWAS summary statistics for 8,090 Europeans, and large-scale expression quantitative trait loci (eQTL) data from the genotype-tissue expression of 53 types of tissues (GTEx v7), we...
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