Article
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
PLoS genetics - 1 Jan 2013
Lauc Gordan, Huffman Jennifer E, Pučić Maja, Zgaga Lina, Adamczyk Barbara, Mužinić Ana, Novokmet Mislav, Polašek Ozren, Gornik Olga, Krištić Jasminka, Keser Toma, Vitart Veronique, Scheijen Blanca, Uh Hae-Won, Molokhia Mariam, Patrick Alan Leslie, McKeigue Paul, Kolčić Ivana, Lukić Ivan Krešimir, Swann Olivia, van Leeuwen Frank N, Ruhaak L Renee, Houwing-Duistermaat Jeanine J, Slagboom P Eline, Beekman Marian, de Craen Anton J M, Deelder André M, Zeng Qiang, Wang Wei, Hastie Nicholas D, Gyllensten Ulf, Wilson James F, Wuhrer Manfred, Wright Alan F, Rudd Pauline M, Hayward Caroline, Aulchenko Yurii, Campbell Harry, Rudan Igor
Abstract excerpt
Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. After isolating IgG from human plasma, we performed 77 quantitative measurements of N-glycosylation using ultra-performance liquid chromatography (UPLC) in 2,247 individuals from four...
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