Article
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases.
Science advances - 1 Feb 2020
Klarić Lucija, Tsepilov Yakov A, Stanton Chloe M, Mangino Massimo, Sikka Timo Tõnis, Esko Tõnu, Pakhomov Eugene, Salo Perttu, Deelen Joris, McGurnaghan Stuart J, Keser Toma, Vučković Frano, Ugrina Ivo, Krištić Jasminka, Gudelj Ivan, Štambuk Jerko, Plomp Rosina, Pučić-Baković Maja, Pavić Tamara, Vilaj Marija, Trbojević-Akmačić Irena, Drake Camilla, Dobrinić Paula, Mlinarec Jelena, Jelušić Barbara, Richmond Anne, Timofeeva Maria, Grishchenko Alexander K, Dmitrieva Julia, Bermingham Mairead L, Sharapov Sodbo Zh, Farrington Susan M, Theodoratou Evropi, Uh Hae-Won, Beekman Marian, Slagboom Eline P, Louis Edouard, Georges Michel, Wuhrer Manfred, Colhoun Helen M, Dunlop Malcolm G, Perola Markus, Fischer Krista, Polasek Ozren, Campbell Harry, Rudan Igor, Wilson James F, Zoldoš Vlatka, Vitart Veronique, Spector Tim, Aulchenko Yurii S, Lauc Gordan, Hayward Caroline
Abstract excerpt
Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been observed in many diseases, but little is understood about the underlying mechanisms. We performed a genome-wide association study of IgG N-glycosylation (N = 8090) and, using a data-driven network approach, suggested how associated...
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