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Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes

23 Jul 2019

Abstract excerpt

Magnesium transporter 1 (MAGT1) critically mediates magnesium homeostasis in eukaryotes and is highly-conserved across different evolutionary branches. In humans, loss–of–function mutations in the MAGT1 gene cause X-linked magnesium deficiency with Epstein-Barr virus (EBV) infection and neoplasia (XMEN), a disease that has a broad range of clinical and immunological consequences. We have previously shown that EBV...

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Iron Metabolism and Disorders
Magnesium in Health and Disease
Parathyroid Disorders and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31337704
DOI: 10.1074/jbc.ra119.008903

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Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genesPMID 31337704Read ↗

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X-linked immunodeficiency with magnesium defect, Epstein–Barr virus infection, and neoplasia diseaseSemantic proximity Read ↗

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Identification of a novel MAGT1 mutation supports a diagnosis of XMEN disease.Semantic proximity Read ↗

Scales of Magt1 Gene: Novel Mutations, Different Presentations.Semantic proximity Read ↗

Mutations in MAGT1 lead to a glycosylation disorder with a variable phenotypeSemantic proximity Read ↗

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