IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion.

doi:10.1097/MIB.0000000000000172

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Article

IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion.

Inflammatory bowel diseases - 1 Oct 2014

Gonsky Rivkah, Deem Richard L, Landers Carol J, Haritunians Talin, Yang Shaohong, Targan Stephan R

Abstract excerpt

BACKGROUND: Mucosal expression of interferon (IFN)-γ plays a pivotal role in the pathogenesis of inflammatory bowel disease (IBD) and IBD risk regions flank IFNG. The conserved IFNG rs1861494 T/C introduces a new CpG methylation site, is associated with disease severity and lack of therapeutic response in other infectious and immune-mediated disorders, and is in linkage disequilibrium with a ulcerative colitis...

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Identifiers

PMID: 25171510
DOI: 10.1097/MIB.0000000000000172
PMCID: PMC4327845

Genes

IFNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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