Article
Attenuated effect of PNPLA3 on hepatic fibrosis by HSD17B13 in Japanese patients with non-alcoholic fatty liver disease.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2020
Seko Yuya, Yamaguchi Kanji, Tochiki Nozomi, Yano Kota, Takahashi Aya, Okishio Shinya, Kataoka Seita, Okuda Keiichiroh, Umemura Atsushi, Moriguchi Michihisa, Tanaka Saiyu, Mori Kojiroh, Okanoue Takeshi, Itoh Yoshito
Abstract excerpt
BACKGROUND & AIMS: PNPLA3 rs738409 has been associated with increased risks of fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Recently, carriage of the rs6834314 G allele, which is in high linkage with rs72613567 of 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13), was reported to be associated with a reduced risk of liver injury in NAFLD patients. We estimated the impact of these genetic...
Read the complete abstract on PubMed