Article
Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease.
BMC medical genetics - 22 Dec 2010
Hotta Kikuko, Yoneda Masato, Hyogo Hideyuki, Ochi Hidenori, Mizusawa Seiho, Ueno Takato, Chayama Kazuaki, Nakajima Atsushi, Nakao Kazuwa, Sekine Akhiro
Abstract excerpt
BACKGROUND: In a genome-wide association scan, the single-nucleotide polymorphism (SNP) rs738409 in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat content. We investigated whether this SNP is associated with the occurrence and progression of nonalcoholic fatty liver disease (NAFLD) in the Japanese population. METHODS: SNP rs738409 was genotyped by the Taqman assay...
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