The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis.

doi:10.1038/ajg.2013.476

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Article

The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis.

The American journal of gastroenterology - 1 Mar 2014

Singal Amit G, Manjunath Hema, Yopp Adam C, Beg Muhammad S, Marrero Jorge A, Gopal Purva, Waljee Akbar K

Abstract excerpt

OBJECTIVES: The PNPLA3 rs738409 single-nucleotide polymorphism is known to promote nonalcoholic steatohepatitis (NASH), but its association with fibrosis severity and hepatocellular carcinoma (HCC) risk is less well-defined. The objectives of this study were to determine the association between PNPLA3 and liver fibrosis severity, HCC risk, and HCC prognosis among patients with liver disease. METHODS: We performed...

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PMID: 24445574
DOI: 10.1038/ajg.2013.476
PMCID: PMC5610907

Genes

PNPLA3

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