Article
Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.
PloS one - 1 Jan 2012
Kawaguchi Takahisa, Sumida Yoshio, Umemura Atsushi, Matsuo Keitaro, Takahashi Meiko, Takamura Toshinari, Yasui Kohichiroh, Saibara Toshiji, Hashimoto Etsuko, Kawanaka Miwa, Watanabe Sumio, Kawata Sumio, Imai Yasuharu, Kokubo Miki, Shima Toshihide, Park Hyohun, Tanaka Hideo, Tajima Kazuo, Yamada Ryo, Matsuda Fumihiko, Okanoue Takeshi
Abstract excerpt
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to cirrhosis and fibrosis, in which a subtype accompanying hepatocyte degeneration and fibrosis is classified as nonalcoholic steatohepatitis (NASH). NASH accounts for approximately 10-30% of NAFLD and causes a higher frequency of liver-related death, and its progression of NASH has been...
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