The greater impact of PNPLA3 polymorphism on liver-related events in Japanese non-alcoholic fatty liver disease patients: A multicentre cohort study.

doi:10.1111/liv.15678

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Article

The greater impact of PNPLA3 polymorphism on liver-related events in Japanese non-alcoholic fatty liver disease patients: A multicentre cohort study.

Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2023

Seko Yuya, Yamaguchi Kanji, Shima Toshihide, Iwaki Michihiro, Takahashi Hirokazu, Kawanaka Miwa, Tanaka Saiyu, Mitsumoto Yasuhide, Yoneda Masato, Nakajima Atsushi, Fjellström Ola, Blau Jenny E, Carlsson Björn, Okanoue Takeshi, Itoh Yoshito

Abstract excerpt

BACKGROUND & AIMS: PNPLA3 rs738409 has been associated with an increased risk of liver-related events in patients with non-alcoholic fatty liver disease (NAFLD). In this study, we investigated the epidemiology of NAFLD and the impact of PNPLA3 on prognosis in Japan. METHODS: A longitudinal multicentre cohort study, the JAGUAR study, includes 1550 patients with biopsy-proven NAFLD in Japan. We performed genetic...

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PMID: 37470077
DOI: 10.1111/liv.15678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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