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R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth

27 Apr 2020

Abstract excerpt

R-spondin2 (RSPO2) is a member of the R-spondin family, which are secreted activators of the WNT/β-catenin (CTNNB1) signaling pathway. In the mouse postnatal ovary, WNT/CTNNB1 signaling is active in the oocyte and in the neighboring supporting cells, the granulosa cells. Although the role of Rspo2 has been previously studied using in vitro experiments, the results are conflicting and the in vivo ovarian function...

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PMID: 32341451
DOI: 10.1038/s41418-020-0547-7

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