Article
RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary.
PloS one - 1 Jan 2011
Chassot Anne-Amandine, Gregoire Elodie P, Lavery Rowena, Taketo Makoto M, de Rooij Dirk G, Adams Ian R, Chaboissier Marie-Christine
Abstract excerpt
Differentiation of germ cells into male gonocytes or female oocytes is a central event in sexual reproduction. Proliferation and differentiation of fetal germ cells depend on the sex of the embryo. In male mouse embryos, germ cell proliferation is regulated by the RNA helicase Mouse Vasa homolog gene and factors synthesized by the somatic Sertoli cells promote gonocyte differentiation. In the female, ovarian...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Cell Differentiation
- Cell Lineage
- Cell Proliferation
- Female
- Fetus
- Fibroblast Growth Factor 9
- Gene Expression Regulation, Developmental
- Male