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Article

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

4 Feb 2008

Abstract excerpt

In mammals, female development has traditionally been considered a default process in the absence of the testis-determining gene, Sry. Recently, it has been documented that the gene for R-spondin1 (RSPO1), a novel class of soluble activator for Wnt/beta-catenin signaling, is mutated in two Italian families with female-to-male (XX) sex reversal. To elucidate the role of Rspo1 as a candidate female-determining gene...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 18250097
DOI: 10.1093/hmg/ddn036

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R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signalingPMID 18250097Read ↗

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<i>Sox8</i> and <i>Sox9</i> act redundantly for ovarian-to-testicular fate reprogramming in the absence of <i>R-spondin1</i> in mouse sex reversalsSemantic proximity Read ↗

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