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Article

R-spondin1, WNT4, and the CTNNB1 signaling pathway: strict control over ovarian differentiation

4 Sept 2014

Abstract excerpt

Sex differentiation is a unique developmental process. Starting from a bipotential gonad, it gives rise to the ovary and the testis, two highly specialized organs that differ morphologically and physiologically despite sharing common reproductive and endocrine functions. This highlights the specific plasticity of the gonadal precursors and the existence of complex antagonistic genetic regulation. Mammalian sex...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 25187620
DOI: 10.1530/rep-14-0177

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