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Article

R-spondin1 and FOXL2act into two distinct cellular types during goat ovarian differentiation

2 Apr 2008

Abstract excerpt

BACKGROUND: Up to now, two loci have been involved in XX sex-reversal in mammals following loss-of-function mutations, PIS (Polled Intersex Syndrome) in goats and R-spondin1 (RSPO1) in humans. Here, we analyze the possible interaction between these two factors during goat gonad development. Furthermore, since functional redundancy between different R-spondins may influence gonad development, we also studied the...

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PMID: 18384673
DOI: 10.1186/1471-213x-8-36

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