Article
Loss of R-spondin1 and Foxl2 amplifies female-to-male sex reversal in XX mice.
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - 1 Jan 2011
Auguste A, Chassot A-A, Grégoire E P, Renault L, Pannetier M, Treier M, Pailhoux Eric, Chaboissier M-C
Abstract excerpt
In vertebrates, 2 main genetic pathways have been shown to regulate ovarian development. Indeed, a loss of function mutations in Rspo1 and Foxl2 promote partial female-to-male sex reversal. In mice, it has been shown that the secreted protein RSPO1 is involved in ovarian differentiation and the transcription factor FOXL2 is required for follicular formation. Here, we analysed the potential interactions between...
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