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Article

The structure of the extracellular domains of human interleukin 11α receptor reveals mechanisms of cytokine engagement.

The Journal of biological chemistry - 12 Jun 2020

Metcalfe Riley D, Aizel Kaheina, Zlatic Courtney O, Nguyen Paul M, Morton Craig J, Lio Daisy Sio-Seng, Cheng Heung-Chin, Dobson Renwick C J, Parker Michael W, Gooley Paul R, Putoczki Tracy L, Griffin Michael D W

Abstract excerpt

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-11Rα, and the β-subunit receptor, gp130. Dysregulated IL-11 signaling has been implicated in several diseases, including some cancers and fibrosis. Mutations in IL-11Rα that reduce signaling are also associated with hereditary cranial malformations. Here we present the first crystal...

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Identifiers

PMID: 32332100
DOI: 10.1074/jbc.RA119.012351
PMCID: PMC7294085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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