Article

Optimization of IL-1Ra Structure to Achieve a Smaller Protein with a Higher Affinity to its Receptor

2021-07-20

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Interleukine-1 family cytokines are key orchestrators of innate and adaptive immunity. In particular, up-regulation of IL-1R1 via its agonistic ligands consisted of IL-1β and IL-1α is implicated in a variety of human diseases, such as rheumatoid arthritis, psoriasis, type I diabetes, amyotrophic lateral sclerosis, and dry-eye disease. Until now, there are no sma...

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Literature Corpus work: 0a86fc95-d781-5f08-bf76-def6552a558f
DOI: 10.21203/rs.3.rs-696354/v1

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