Article

Alterations in secondary structure and binding affinity from mutations in the interleukin-1 receptor antagonist

2024-07-17

Abstract excerpt

<h4> Abstract </h4> Deficiency of Interleukin-1 receptor antagonist (DIRA) is a rare autosomal recessive autoinflammatory disorder that occurs during the neonatal period, manifesting a spectrum of symptoms including but not limited to osteomyelitis and pustulosis. This disease results from loss-of-function mutations in the IL1RN gene, encoding the IL-1 receptor antagonist (IL-1Ra). The dysfunction of IL-1Ra may ar...

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Literature Corpus work: 24709095-d115-5c8c-b822-9eeae4691b7c
DOI: 10.1101/2024.07.13.24310367

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