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Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

7 Mar 2024

Abstract excerpt

IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses. Here we solve the cryoEM structure of the IL-11 receptor recognition complex to discover how differences in gp130-binding interfaces may drive signalling outcomes. We explore how mutations in the IL6ST gene encoding for gp130,...

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PMID: 38453915
DOI: 10.1038/s41467-024-46235-6

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