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Article

The structure of the IL-11 signalling complex provides insight into receptor variants associated with craniosynostosis.

The FEBS journal - 1 Feb 2025

Sentosa Darlene D, Metcalfe Riley D, Sims Natalie A, Putoczki Tracy L, Griffin Michael D W

Abstract excerpt

Interleukin 11 (IL-11), a member of the IL-6 family of cytokines, has roles in haematopoiesis, inflammation, bone metabolism, and craniofacial development. IL-11 also has pathological roles in chronic inflammatory diseases, fibrosis, and cancer. In this structural snapshot, we explore our recently published cryo-EM structure of the human IL-11 signalling complex to understand the molecular mechanisms of complex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39462650
DOI: 10.1111/febs.17307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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