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Article

Interleukin-11 signals through the formation of a hexameric receptor complex.

The Journal of biological chemistry - 17 Nov 2000

Barton V A, Hall M A, Hudson K R, Heath J K

Abstract excerpt

Interleukin-11 (IL-11) is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor gp130. IL-11 has been shown to induce gp130-dependent signaling through the formation of a high affinity complex with the IL-11 receptor (IL-11R) and gp130. Site-directed mutagenesis studies...

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Source

Identifiers

PMID: 10948192
DOI: 10.1074/jbc.M004648200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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