Article
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Cancer cell - 11 May 2020
Di Genua Cristina, Valletta Simona, Buono Mario, Stoilova Bilyana, Sweeney Connor, Rodriguez-Meira Alba, Grover Amit, Drissen Roy, Meng Yiran, Beveridge Ryan, Aboukhalil Zahra, Karamitros Dimitris, Belderbos Mirjam E, Bystrykh Leonid, Thongjuea Supat, Vyas Paresh, Nerlov Claus
Abstract excerpt
Acute erythroid leukemia (AEL) commonly involves both myeloid and erythroid lineage transformation. However, the mutations that cause AEL and the cell(s) that sustain the bilineage leukemia phenotype remain unknown. We here show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations cooperatively induce bilineage AEL, and that the major leukemia-initiating cell (LIC) population has a...
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