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Article

C/EBPα: critical at the origin of leukemic transformation

6 Jan 2014

Abstract excerpt

Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by clonal expansion of myeloid progenitor cells. A major mechanistic theme in AML biology is the extensive collaboration among fusion oncoproteins, transcription factors, and chromatin regulators to initiate and sustain a transformed cellular state. A new study in this issue describes how the C/EBPα transcription factor is crucial for the...

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PMID: 24395889
DOI: 10.1084/jem.20132530

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