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Article

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation.

Nature communications - 23 Apr 2020

Kuo Yi-Chun, Chen Hua, Shang Guijun, Uchikawa Emiko, Tian Hui, Bai Xiao-Chen, Zhang Xuewu

Abstract excerpt

Plexins are receptors for semaphorins that transduce signals for regulating neuronal development and other processes. Plexins are single-pass transmembrane proteins with multiple domains in both the extracellular and intracellular regions. Semaphorin activates plexin by binding to its extracellular N-terminal Sema domain, inducing the active dimer of the plexin intracellular region. The mechanism underlying this...

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Identifiers

PMID: 32327662
DOI: 10.1038/s41467-020-15862-0
PMCID: PMC7181871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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