Article

The cryo-EM structure of the neurofibromin dimer reveals the molecular basis for von Recklinghausen disease

2021-02-18

Abstract excerpt

Neurofibromin (NF1) is a tumour suppressor mutated in neurofibromatosis type 1 (von Recklinghausen disease), one of the most common human genetic diseases(1). NF1 regulates cellular growth through suppressing the Rat Sarcoma (RAS) pathway and, accordingly, mutations in this protein drive numerous cancers, including melanoma, ovarian, breast and brain cancer(2, 3). Currently, however, the molecular basis for NF1 fu...

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Literature Corpus work: 886194c6-54c2-5837-a6ee-e62fdb19c5a2
DOI: 10.1101/2021.02.18.431788

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