Article

The Structural Basis for Pacs1-Wdr37 Complex Assembly and Stability

2025-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Phosphofurin acidic cluster sorting protein 1 (Pacs1) is a multidomain adaptor proposed to bind transmembrane cargo proteins to facilitate their intracellular trafficking. Pacs1 also forms a complex with WD-repeat protein 37 (Wdr37), which is essential for lymphocyte homeostasis. Despite numerous proposed binding partners, a validated structure for Pacs1-containing protein complexes is lacking....

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Literature Corpus work: 2e30d071-76b1-5703-9018-73377b51ae42
DOI: 10.1101/2025.11.05.686565

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