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Article

Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex.

Nature communications - 26 May 2021

Lu Defen, Shang Guijun, He Xiaojing, Bai Xiao-Chen, Zhang Xuewu

Abstract excerpt

Secreted class 3 semaphorins (Sema3s) form tripartite complexes with the plexin receptor and neuropilin coreceptor, which are both transmembrane proteins that together mediate semaphorin signal for neuronal axon guidance and other processes. Despite extensive investigations, the overall architecture of and the molecular interactions in the Sema3/plexin/neuropilin complex are incompletely understood. Here we...

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Identifiers

PMID: 34039996
DOI: 10.1038/s41467-021-23541-x
PMCID: PMC8155012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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