Article

Structural basis of neurofibromin tetramerization and dimer-tetramer equilibrium

2025-02-16

Abstract excerpt

Human neurofibromin (NF1) is a tumor suppressor multidomain protein known to regulate cellular functions as a dimer. Using cryo-EM, we discovered that neurofibromin can form more highly organized structures and describe tetramerization and a dynamic dimer-to-tetramer equilibrium with extensive interlocked interfaces as well as structural flexibility. The new tetramer structure generates and modifies interaction su...

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Literature Corpus work: 4d6f9447-49e9-5736-9f26-37211ab5305e
DOI: 10.1101/2025.02.13.638105

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