Article
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.
Nature genetics - 1 Oct 2017
Kemp John P, Morris John A, Medina-Gomez Carolina, Forgetta Vincenzo, Warrington Nicole M, Youlten Scott E, Zheng Jie, Gregson Celia L, Grundberg Elin, Trajanoska Katerina, Logan John G, Pollard Andrea S, Sparkes Penny C, Ghirardello Elena J, Allen Rebecca, Leitch Victoria D, Butterfield Natalie C, Komla-Ebri Davide, Adoum Anne-Tounsia, Curry Katharine F, White Jacqueline K, Kussy Fiona, Greenlaw Keelin M, Xu Changjiang, Harvey Nicholas C, Cooper Cyrus, Adams David J, Greenwood Celia M T, Maurano Matthew T, Kaptoge Stephen, Rivadeneira Fernando, Tobias Jonathan H, Croucher Peter I, Ackert-Bicknell Cheryl L, Bassett J H Duncan, Williams Graham R, Richards J Brent, Evans David M
Abstract excerpt
Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 individuals from the UK Biobank to identify loci associated with BMD as estimated by quantitative ultrasound of the heel. We identified 307 conditionally independent single-nucleotide polymorphisms (SNPs) that attained genome-wide significance at 203...
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