Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Novel Pleiotropic SNPs Associated with Osteoporosis and Rheumatoid Arthritis.

Calcified tissue international - 1 Jul 2021

Liu Ying-Qi, Liu Yong, Zhang Qiang, Xiao Tao, Deng Hong-Wen

Abstract excerpt

Genome-wide association studies (GWASs) have identified hundreds of genetic loci for osteoporosis (OP) and rheumatoid arthritis (RA), individually, however, a large proportion of the total trait heritability remains unexplained. Previous studies demonstrated that these two diseases may share some common genetic determination and risk factors, but they were generally focused on individual trait and failed to...

Topics

Join the communities discussing this publication.

Arthritis, Rheumatoid
Bone Density
Genetic Predisposition to Disease
Genome-Wide Association Study
Osteoporosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

Open in PubMed Open full text

Identifiers

PMID: 33740106
DOI: 10.1007/s00223-021-00817-4
PMCID: PMC8238865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Novel Pleiotropic SNPs Associated with Osteoporosis and Rheumatoid Arthritis.PMID 33740106Read ↗

Identification of novel genetic loci for osteoporosis and/or rheumatoid arthritis using cFDR approach.Semantic proximity Read ↗

Rheumatoid arthritis and osteoporosis: shared genetic effect, pleiotropy and causality.Semantic proximity Read ↗

Pleiotropic genomic variants at 17q21.31 associated with bone mineral density and body fat mass: a bivariate genome-wide association analysis.Semantic proximity Read ↗

Identification of Novel Potentially Pleiotropic Variants Associated With Osteoporosis and Obesity Using the cFDR Method.Semantic proximity Read ↗

Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method.Semantic proximity Read ↗

Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways.Semantic proximity Read ↗

Shared Genetic Architecture Between Rheumatoid Arthritis and Varying Osteoporotic Phenotypes.Semantic proximity Read ↗

Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applicationsSemantic proximity Read ↗

Leveraging osteoclast genetic regulatory data to identify genes with a role in osteoarthritis.Semantic proximity Read ↗

Integrating genome-wide association and transcriptome predicted model identify novel target genes with osteoporosisSemantic proximity Read ↗

Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.Semantic proximity Read ↗

Pleiotropic loci underlying bone mineral density and bone size identified by a bivariate genome-wide association analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.