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Article

Bivariate genome-wide association analyses identified genes with pleiotropic effects for femoral neck bone geometry and age at menarche.

PloS one - 1 Jan 2013

Ran Shu, Pei Yu-Fang, Liu Yong-Jun, Zhang Lei, Han Ying-Ying, Hai Rong, Tian Qing, Lin Yong, Yang Tie-Lin, Guo Yan-Fang, Shen Hui, Thethi Inderpal S, Zhu Xue-Zhen, Deng Hong-Wen

Abstract excerpt

Femoral neck geometric parameters (FNGPs), which include cortical thickness (CT), periosteal diameter (W), buckling ratio (BR), cross-sectional area (CSA), and section modulus (Z), contribute to bone strength and may predict hip fracture risk. Age at menarche (AAM) is an important risk factor for osteoporosis and bone fractures in women. Some FNGPs are genetically correlated with AAM. In this study, we performed...

Topics

Adult
Age Factors
Aged
Asian People
Female
Femur Neck
Genome-Wide Association Study
Genotype
Humans
Linkage Disequilibrium
Menarche

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Phenotype

Polymorphism, Single Nucleotide

White People

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 23593202
DOI: 10.1371/journal.pone.0060362
PMCID: PMC3617200

Genes

IDS
NRCAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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