Article
A bivariate whole genome linkage study identified genomic regions influencing both BMD and bone structure.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2008
Liu Xiao-Gang, Liu Yong-Jun, Liu Jianfeng, Pei Yufang, Xiong Dong-Hai, Shen Hui, Deng Hong-Yi, Papasian Christopher J, Drees Betty M, Hamilton James J, Recker Robert R, Deng Hong-Wen
Abstract excerpt
Areal BMD (aBMD) and areal bone size (ABS) are biologically correlated traits and are each important determinants of bone strength and risk of fractures. Studies showed that aBMD and ABS are genetically correlated, indicating that they may share some common genetic factors, which, however, are largely unknown. To study the genetic factors influencing both aBMD and ABS, bivariate whole genome linkage analyses were...
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