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Article

Oncogenic ALK F1174L drives tumorigenesis in cutaneous squamous cell carcinoma.

Life science alliance - 1 Jun 2020

Gualandi Marco, Iorio Maria, Engeler Olivia, Serra-Roma André, Gasparre Giuseppe, Schulte Johannes H, Hohl Daniel, Shakhova Olga

Abstract excerpt

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer characterized by increased mortality. Here, we show for the first time that anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor superfamily, plays a pivotal role in the pathogenesis of cSCC. Our data demonstrate that the overexpression of the constitutively active, mutated ALK, ALK F1174L , is...

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Identifiers

PMID: 32312912
DOI: 10.26508/lsa.201900601
PMCID: PMC7184028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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