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Article

Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma.

International journal of cancer - 15 Dec 2010

Claerhout Sofie, Verschooten Lien, Van Kelst Sofie, De Vos Rita, Proby Charlotte, Agostinis Patrizia, Garmyn Marjan

Abstract excerpt

Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in the Caucasian population. Although early stages of skin cancer have a high curability and excellent prognosis, advanced cSCC shows resistance to chemotherapy, including cisplatin. The PI3-K/AKT pathway is known to have a role in both skin cancer development and resistance to therapeutic drugs. In this study, we used isogenic cell lines...

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Source

Identifiers

PMID: 21351258
DOI: 10.1002/ijc.25300

Genes

AKT1
ATG5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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