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Targeted Therapy Against the Cell of Origin in Cutaneous Squamous Cell Carcinoma

5 May 2019

Abstract excerpt

Squamous cell carcinomas (SCC), including cutaneous SCCs, are by far the most frequent cancers in humans, accounting for 80% of all newly diagnosed malignancies worldwide. The old dogma that SCC develops exclusively from stem cells (SC) has now changed to include progenitors, transit-amplifying and differentiated short-lived cells. Accumulation of specific oncogenic mutations is required to induce SCC from each...

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PMID: 31060263
DOI: 10.3390/ijms20092201

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