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Characterization of Antigen Escape Mutations in Chronic HBV-Infected Patients in Upper Egypt

1 Jun 2021

Abstract excerpt

BACKGROUND: Mutations within the "a" determinant region (position 124-147) that is present in the major hydrophilic region (MHR, position 99-160) of the hepatitis B surface antigen (HBsAg) are associated with vaccine-escape, lack of diagnosis, and failure to hepatitis B immunoglobulin (HBIG) therapy. Data regarding the amino acid changes of "a" determinant region of HBsAg are limited in Egypt. The prevalence and...

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PMID: 34234472
DOI: 10.2147/idr.s315299

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