Mutations in the S gene region of hepatitis B virus genotype D in Golestan Province-Iran.

doi:10.1007/s11262-012-0715-z

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Mutations in the S gene region of hepatitis B virus genotype D in Golestan Province-Iran.

Virus genes - 1 Jun 2012

Moradi Abdolvahab, Zhand Sareh, Ghaemi Amir, Javid Naeme, Tabarraei Alijan

Abstract excerpt

Mutations of HBsAg especially within the "a" determinant could alter the antigenicity of the protein causing failure of HBsAg neutralization and escaping from the host's immune system, resulting in active viral replication and liver disease. This project aimed to investigate mutation in the S gene region of HBV infected patients in Golestan Province-Iran. HBV-DNA extractions from plasma and PCR of 100 patients...

Topics

Adult
Cluster Analysis
DNA, Viral
Epitopes, B-Lymphocyte
Epitopes, T-Lymphocyte
Female
Frameshift Mutation
Genotype
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Iran

Male

Mutation, Missense

Plasma

Point Mutation

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 22274739
DOI: 10.1007/s11262-012-0715-z

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