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Do the circulating Pre-S/S quasispecies influence hepatitis B virus surface antigen levels in the HBeAg negative phase of HBV infection?

Alimentary pharmacology & therapeutics - 1 Jun 2020

Cavallone Daniela, Ricco Gabriele, Oliveri Filippo, Colombatto Piero, Moriconi Francesco, Coco Barbara, Romagnoli Veronica, Salvati Antonio, Surace Lidia, Bonino Ferruccio, Brunetto Maurizia Rossana

Abstract excerpt

BACKGROUND: Virus, host factors and their interplay influence Hepatitis B surface Antigen serum levels during Hepatitis B Virus (HBV) infection course and treatment. AIM: To study the Pre-S/S circulating quasispecies in a cohort of untreated, HBeAg negative, genotype-D, HBsAg carriers. METHODS: We studied 260 carriers: 71 with HBeAg negative infection (ENI; HBV-DNA ≤2000 IU/mL); 42 Grey Zone (GZ; HBV-DNA...

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PMID: 32390175
DOI: 10.1111/apt.15753

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