HDV Can Constrain HBV Genetic Evolution in HBsAg: Implications for the Identification of Innovative Pharmacological Targets.

doi:10.3390/v10070363

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Article

HDV Can Constrain HBV Genetic Evolution in HBsAg: Implications for the Identification of Innovative Pharmacological Targets.

Viruses - 9 Jul 2018

Colagrossi Luna, Salpini Romina, Scutari Rossana, Carioti Luca, Battisti Arianna, Piermatteo Lorenzo, Bertoli Ada, Fabeni Lavinia, Minichini Carmine, Trimoulet Pascale, Fleury Hervé, Nebuloso Elena, De Cristofaro Maria, Cappiello Giuseppina, Spanò Alberto, Malagnino Vincenzo, Mari Terenzio, Barlattani Angelo, Iapadre Nerio, Lichtner Miriam, Mastroianni Claudio, Lenci Ilaria, Pasquazzi Caterina, De Sanctis Giuseppe Maria, Galeota Lanza Alfonso, Stanzione Maria, Stornaiuolo Gianfranca, Marignani Massimo, Sarmati Loredana, Andreoni Massimo, Angelico Mario, Ceccherini-Silberstein Francesca, Perno Carlo-Federico, Coppola Nicola, Svicher Valentina

Abstract excerpt

Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection. However, to-date no direct anti-HDV drugs are available in clinical practice. Here, we identified conserved and variable regions in HBsAg and HDAg domains in HBV + HDV infection, a critical finding for the design of innovative...

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Identifiers

PMID: 29987240
DOI: 10.3390/v10070363
PMCID: PMC6071122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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