Article
Artemisinin Action and Resistance in Plasmodium falciparum.
Trends in parasitology - 1 Sept 2016
Tilley Leann, Straimer Judith, Gnädig Nina F, Ralph Stuart A, Fidock David A
Abstract excerpt
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in recent years to a substantial reduction in deaths resulting from Plasmodium falciparum malaria. Resistance to artemisinins, however, has emerged in Southeast Asia. Clinically, resistance is defined as a slower rate of parasite clearance in patients treated with an artemisinin derivative or an ACT. These slow clearance rates...
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