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Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral Defense

7 Apr 2020

Abstract excerpt

Wild mammalian species, including bats, constitute the natural reservoir of betacoronavirus (including SARS, MERS, and the deadly SARS-CoV-2). Different hosts or host tissues provide different cellular environments, especially different antiviral and RNA modification activities that can alter RNA modification signatures observed in the viral RNA genome. The zinc finger antiviral protein (ZAP) binds specifically...

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PMID: 32289821
DOI: 10.1093/molbev/msaa094

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