Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans

19 Oct 2020

Abstract excerpt

Although interferons inhibit SARS-CoV-2 and have been evaluated for treatment of coronavirus disease 2019 (COVID-19), the most effective types and antiviral effectors remain to be defined. Here, we show that IFN-γ is particularly potent in restricting SARS-CoV-2 and in inducing expression of the antiviral factor ZAP in human lung cells. Knockdown experiments revealed that endogenous ZAP significantly restricts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Respiratory viral infections research
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33067384
DOI: 10.1128/mbio.01930-20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in HumansPMID 33067384Read ↗

Differences in innate Intracellular viral suppression competencies may explain variations in morbidity and mortality from SARS-CoV-2 infectionSemantic proximity Read ↗

Origin and evolution of the Zinc Finger Antiviral ProteinSemantic proximity Read ↗

Origin and evolution of the zinc finger antiviral proteinSemantic proximity Read ↗

Zinc finger antiviral protein (ZAP) activity in mammalian and avian hosts in CpG and UpA-mediated restriction of RNA viruses and investigation of ZAP-mediated shaping of host transcriptome compositionsSemantic proximity Read ↗

HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levelsSemantic proximity Read ↗

The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts human cytomegalovirusSemantic proximity Read ↗

Alphavirus Evasion of Zinc Finger Antiviral Protein (ZAP) Correlates with CpG Suppression in a Specific Viral nsP2 Gene SequenceSemantic proximity Read ↗

The Slowing Rate of CpG Depletion in SARS-CoV-2 Genomes Is Consistent with Adaptations to the Human HostSemantic proximity Read ↗

Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral DefenseSemantic proximity Read ↗

Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral SystemSemantic proximity Read ↗

Comparison of CpG- and UpA-mediated restriction of RNA virus replication in mammalian and avian cells and investigation of potential ZAP-mediated shaping of host transcriptome compositionsSemantic proximity Read ↗

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early 1 geneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.